Endocrine Abstracts

As the major end product of purine metabolism urate is produced by most adults at the rate of 700 mg/day. Although a small proportion of the urate pool may by derived from the diet the greatest amount results from tissue breakdown. Both hyperuricaemia and gout occur with increased frequency in hyperparathyroidism (PHPT). PHPT is associated with a high bone turnover and increased turnover of nucleic acid of cellular origin. Urate metabolism was studied in 106 patients with PHPT...